Saturday, August 11, 2007

Common Treatments for Diabetes Destroy the Pancreas and Leads to Worsening


A class of drugs called thiazolidinediones (TZDs), and specifically the brand name drug Avandia, were found to drastically increase the rate of heart attack. Given that 70% of diabetics already die of heart-related complications, an increase in this risk is devastating. The next punch came from an article in the September issue of Diabetes Research and Clinical Practice. Researchers confirmed earlier findings that another popular class of diabetic drugs, the sulfonylureas (such as brand name Glyburide), actually kill off the cells in the pancreas that make insulin, virtually ensuring that these patients will end up worsening and needing to inject insulin!!

Article from: http://www.sciencedirect.com/

Sulfonylurea and glinide reduce insulin content, functional expression of KATP channels, and accelerate apoptotic β-cell death in the chronic phase

Abstract

We previously found that chronic exposure to glibenclamide inhibits acute glibenclamide-induced insulin secretion by reducing the number of functional ATP-sensitive K+ (KATP) channels on the plasma membrane of pancreatic β-cells. In the present study, we compared sulfonylurea-induced and glinide-induced insulin secretion in pancreatic β-cells chronically exposed to these widely used oral hypoglycemic agents. Chronic exposure of pancreatic β-cells to sulfonylureas (glibenclamide or tolbutamide) and glinide (nateglinide) similarly impaired their acute effectiveness by reducing the insulin content and the number of functional KATP channels on the plasma membrane. Functional expression of the voltage-dependent Ca2+ channels (VDCCs), ion channels that play a critical role in the KATP channel dependent insulin secretory pathway, was similar to that in drug-untreated cells. Chronic exposure to each of the three agents similarly accelerated apoptotic β-cell death. Thus, reduction of the insulin content, reduction of the number of functional KATP channels on the plasma membrane, and acceleration of apoptotic β-cell death all are involved in impaired insulinotropic agent-induced acute insulin secretion in the chronic phase of sulfonylurea and glinide treatment. These findings help to clarify the mechanism of secondary failure after long-term therapy by these hypoglycemic agents, and should have important clinical implications regarding pharmacotherapy for type 2 diabetes.


Abbreviations: KATP, ATP-sensitive K+; VDCCs, voltage-dependent Ca2+ channels; DMEM, Dulbecco's modified Eagle's medium; KRBB, Krebs–Ringer bicarbonate buffer; RIA, radioimmunoassay; TUNEL, TdT-mediated dUTP nick end labeling; PBS, phosphate buffered saline; DMSO, dimethylsulfoxide

Akira Takahashia, b, Kazuaki Nagashimaa, , , Akihiro Hamasakia, Naomitsu Kuwamuraa, Yukiko Kawasakia, Hiroki Ikedaa, Yuichiro Yamadaa, Nobuya Inagakia, c and Yutaka Seinoa, d
aDepartment of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
bNakamura Hospital, Osaka, Japan
cCREST of Japan Science and Technology Cooperation (JST), Kyoto, Japan
dKansai Denryoku Hospital, Osaka, Japan

Monday, August 6, 2007

Mahjong game 'can cause epilepsy'



By Vaudine England
BBC News, Hong Kong


The study said the syndrome affects more men than women
A study by doctors in Hong Kong has concluded that epilepsy can be induced by the Chinese tile game of mahjong.

The findings, published in the Hong Kong Medical Journal, are based on 23 cases of people who suffered mahjong-induced seizures.

The report's four authors, from Hong Kong's Queen Mary Hospital, said the best prevention - and cure - was to avoid playing mahjong.

The study led the doctors to define mahjong epilepsy as a unique syndrome.

Epileptic seizures can be provoked by a wide variety of triggers, but one cause increasingly evident to researchers is the playing - or even watching - of mahjong.

This Chinese tile game, played by four people around a table, can involve gambling and quickly becomes compulsive.

Demanding

The game, which is intensely social and is sometimes played in crowded mahjong parlours, involves the rapid movement of tiles in marathon sessions.

The doctors conclude that the syndrome affects far more men than women; that their average age is 54; and that it can hit sufferers anywhere between one to 11 hours into a mahjong game.

They say the attacks are not just caused by sleep deprivation or gambling stress.

Mahjong is cognitively demanding, drawing on memory, fast calculations, concentration, reasoning and sequencing.

The distinctive design of mahjong tiles, and the sound of the tiles crashing onto the table, may contribute to the syndrome.

The propensity of Chinese people to play mahjong also deserves further study, the doctors say.

What is certain though, is that the only sure way to avoid mahjong epilepsy, is to avoid mahjong which, for many people, is easier said than done.

LIES!: Surgery for Money


Monte Sereno doctor accused of faking patients' need for surgery By Barbara Feder Ostrov Mercury News

On the day of his cancer treatment, 87-year-old Dung Le lay on a table, his frail body sedated as needles loaded with radioactive seeds were inserted into his prostate to destroy the malignant tissue his doctor told him was there.

But Dung Le never had cancer, and his doctor knew it.

Now that doctor, Ali Moayed of Monte Sereno, faces felony charges of battery, elder abuse and fraud for his treatment of Le, in a bizarre case that has deeply unsettled local physicians. Two other men in their 70s, their medical files falsified by Moayed, narrowly escaped the same unnecessary procedure, according to a state medical board investigator's report.

Santa Clara County prosecutors are also investigating whether Moayed - who has pleaded not guilty to the charges - may have harmed 13 other men in a similar scheme.

"He doctored the pathology reports to induce a patient to undergo a procedure that carried a significant risk," said Santa Clara County prosecutor Bill Butler. "The conduct was so egregious, it goes beyond simply medical malpractice."

Sparked by a colleague's discovery of altered lab reports, the unraveling of Moayed's alleged deceptions spanned two years of investigation by several agencies, leading to his arrest in late June.

But the question remains: Why would a prosperous doctor risk his career this way? Was it greed? A misguided sense that he was doing the right thing for his patients?

Free on $500,000 bail but currently barred from practicing medicine, the 41-year-old urologist faces more than seven years in prison and potential civil lawsuits that could bankrupt him.

Moayed did not return phone calls or e-mails from the Mercury News and his attorney declined to comment. Yet hints about Moayed's motivation are found in the normally confidential medical board investigator's report placed in his court file.

Missing report in '05 A missing pathology report proved to be Moayed's undoing. In May 2005, Dr. Abhinand Peddada, a Los Gatos radiation oncologist, was reviewing the medical files of one of Moayed's patients, identified only as "S.B.," 75, who was scheduled for a prostate cancer treatment known as brachytherapy.

The procedure isn't pleasant: It involves sedating the patient, then inserting radioactive seeds the size of rice grains into the prostate to shrink tumors.

As Peddada scrutinized the file to confirm the patient's post-surgery treatment plan, he noticed that a crucial lab report confirming the cancer diagnosis was missing.

He called Moayed's medical office in Los Gatos first, then the lab that had examined a sample of tissue taken from the patient's prostate. Two pathology reports came in. The first one, from the lab, said the patient was cancer-free. The second - from Moayed's office - said the opposite. Peddada suspected that the report from Moayed's office had been altered. S.B.'s procedure was immediately canceled.

Good Samaritan Hospital in San Jose, where both Peddada and Moayed were on staff, began to investigate. When Peddada, hospital administrators and other physicians reviewed the files of Moayed's other patients, they found that pathology reports for Dung Le and another patient, referred to in medical board documents as "B.T.," 75, were falsified. They were able to cancel B.T.'s upcoming brachytherapy.

But for Dung Le, it was too late.

Hospital findings Good Samaritan officials quickly reported their findings to the state medical board, law enforcement and Los Gatos Community Hospital, where Moayed also was on staff. The medical board and the Santa Clara County District Attorney's Office opened investigations.

By August 2005, Moayed, on the advice of his lawyer, had resigned from the medical staffs at both hospitals.

He relinquished his medical license the next month, and his practice was taken over by Dr. Farshad Nowzari, according to the investigator's report. Until this incident, Moayed had never been investigated or disciplined by the state medical board.

Once Moayed stopped practicing medicine, investigators could take their time to build a case. As Peddada dug deeper into Moayed's patients' files, his concerns grew. There were other aspects of Moayed's treatment of cancer patients that were difficult to fathom.

Moayed gave some of his patients hormone injections to prevent their prostate cancer from progressing, but according to their medical files, they didn't appear to show effects of the treatment - almost as if they had been given a placebo, Peddada told investigators.

He called Moayed to ask if he had received "a bad batch" of hormones, the report says. After Moayed got that call, Peddada told investigators, the patients began to show the response to the treatment that should have occurred all along. Peddada declined to speak with the Mercury News.

Much to lose Moayed had a great deal to lose from his apparent deceptions. A 1991 graduate from the University of Cincinnati Medical School, Moayed owns a medical building and lives in a Monte Sereno mansion with an estimated value of more than $3 million.

He admitted to the medical board investigator that he had falsified the reports for three cancer-free patients, inserting lab results from patients who did have cancer.

He said he didn't do it for the money. Each brachytherapy procedure would have netted him only $600 because they are performed alongside a radiation oncologist, he told investigators.

Why, then, would he lie to his patients? The investigative report isn't clear, but Moayed appears to claim that the brachytherapies would help them by preventing future cancers. At least one of his patients had displayed early warning signs, including an elevated PSA (prostate specific antigen) level. Moayed "felt the patients were on the brink of getting cancer and that he wanted to give them a definitive answer," the report says.

"He knows he messed up and that he will no longer be practicing medicine," the investigator wrote in the report. "He stated that there was no justification for what he did."

Moayed said "he was under a lot of stress," logging many after-work hours on his computer instead of spending time with his children, the investigator reported.

Treatment debated In medical circles, the best way to treat prostate cancer is fiercely debated.

The disease afflicts more than 218,000 American men each year, many of them elderly. An estimated 20 percent of American men will be diagnosed with the disease between the ages of 70 and 75, according to the National Cancer Institute.

Once cancer is detected, treatment options range from "watchful waiting" (in which patients are closely monitored but not treated) to hormone or radiation therapy, to surgery.

But an independent doctor who reviewed evidence in the case told medical board investigators that Moayed's apparent conviction that his patients ultimately would develop cancer, based on the early warning signs, simply wasn't valid. Nor should a doctor pursue cancer treatments for a patient whose cancer has not been confirmed, the independent doctor said.

Many doctors believe that elderly patients are more likely to die of other causes, such as heart disease, before they die of prostate cancer. Moayed told the investigator he had "messed up" with only three patients, but local prosecutors and the medical board investigator are examining his treatment of more than a dozen other patients from Los Gatos Community Hospital. Dr. Domenico Manzone, a Los Gatos urologist, told the medical board investigator that Moayed had performed 13 other brachytherapy procedures at the Silicon Valley Urology Center at Los Gatos Community Hospital. But when Manzone reviewed the patients' charts, he found no reports documenting their cancer - only a statement from Moayed that they had the disease, the investigator's report says.

Manzone declined to speak about Moayed. But in an e-mail, he said, "The dedicated and hardworking physicians" of the Silicon Valley Urology Center "deplore the apparent breaches by Ali Moayed of some of the most fundamental principles of our profession."

Hearing not set A date for Moayed's preliminary hearing hasn't been set yet, but the criminal charges against him are the only the start of his legal woes. He could face malpractice lawsuits that wouldn't be subject to California's $250,000 damages cap because of the age of the victims, said prominent San Jose attorney Dick Alexander. If a jury finds him guilty of willful misconduct, the doctor's malpractice insurance would not cover him.

It's unusual, but not unheard of, for prosecutors to file criminal charges against doctors over medical treatment, said David Magnus, a Stanford University medical ethicist. Such cases are typically handled by state medical boards, which can revoke a doctor's license, and in civil courts through malpractice lawsuits.

If the facts of Moayed's case are true, Magnus said, they represent a doctor out of control.

"That kind of blatant paternalism might have been common in this country in the 1940s and 1950s, but it's inappropriate and something that won't be countenanced today," Magnus said. "You can't knowingly, intentionally lie to patients to get them to do what you want."

Sunday, August 5, 2007

Drunk on Vit D


Vitamin D intoxication that is associated with the consumption of dietary supplements is reported rarely.1 In 2004, the Food and Drug Administration (FDA) learned of the following case.

A 58-year-old woman with diabetes mellitus and rheumatoid arthritis began taking a dietary supplement called Solutions IE Ageless Formula II on January 12, 2004. Fatigue, constipation, back pain, forgetfulness, nausea, and vomiting soon developed.

On March 15, 2004, she was hospitalized because her speech was slurred, and a blood glucose reading taken at home was 30 mg per deciliter. On admission, her serum levels were as follows: calcium, more than 3.75 mmol per liter; 25-hydroxyvitamin D, 1171 nmol per liter (normal range, 22 to 135); 1,25-dihydroxyvitamin D, 305 pmol per liter (normal range, 36 to 144); parathyroid hormone, 12 ng per liter (normal range, 10 to 65); calcitonin, 4.5 ng per liter (normal range, 0 to 4.6); albumin, 31 g per liter; phosphorus, 0.81 mmol per liter; blood urea nitrogen, 18.6 mmol per liter; and creatinine, 265 µmol per liter.

The patient was treated with intravenous normal saline, furosemide, and pamidronate disodium.

On March 19, 2004, while still hospitalized, she was informed by the product distributor of an error in product formulation such that 188,640 IU of vitamin D3 had been added to the daily serving size of six capsules instead of the intended 400 IU.

At discharge on March 24, the patient's serum levels were as follows: calcium, 2.60 mmol per liter; blood urea nitrogen, 10.0 mmol per liter; and creatinine, 221 µmol per liter.

The patient died from a cause unknown to us on January 8, 2005.

Laboratory analysis of the product by the FDA, obtained from one of two lots reportedly overfortified with vitamin D3, revealed 186,906 IU of vitamin D3 in each serving size of six capsules, indicating that the patient had consumed roughly 90 times the recommended safe upper limit of 2000 IU per day.

Long-term daily vitamin D consumption of more than 40,000 IU (1000 µg) is needed to cause hypercalcemia in healthy persons.2

In March 2004, the product distributor announced that during the previous month it had received three complaints from customers who had been hospitalized for hypercalcemia and vitamin D toxicity. The same month, the product manufacturer recalled 1600 bottles of the product.

The case described here underscores the need for the manufacturers of dietary supplements to rigorously monitor levels of ingredients in products and for physicians to be aware of supplements their patients may be taking.

Karl C. Klontz, M.D.
David W. Acheson, M.D.
Food and Drug Administration
College Park, MD 20740

References

Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-67.
Veith R. Do we really need 100 µg vitamin D/d, and is it safe for all of us? Am J Clin Nutr 2001;74:862-864.

Friday, August 3, 2007

Free Music



Our friends at Magnatunes have a free gift for you:

We made it just for you: The Art of Persuasion features over 70 minutes of Magnatune's most compelling artists at their most subdued and seductive. This isn't just a compilation, it's a mix—a thoughtfully assembled playlist of sophisticated downtempo tracks that flow into one another, by best-selling performers like Artemis, Yongen, Paul Avgerinos, Lisa DeBenedictis, and eight others. The perfect album to have on hand for dinners, drinks, and uh...other nighttime pursuits.

To sample the album: http://magnatune.com/artists/albums/magnacomp-persuasion/

To download your free copy: http://magnatune.com/freemusic
Just insert your email address and they will send you the password and link to download the album. Magnatunes will NEVER give your email address to anyone. They just want to tell you about the great artists they represent.

Here is why you should buy from Magnatunes:http://magnatune.com/info/whynotevil

Why we are Not Evil !

Licensing: all our music can be licensed for commercial use instantly and online. We license more music online than anyone else in the world (over 1000 licenses in our 4 years of business).

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